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Eur J Clin Microbiol Infect Dis. 2009 Apr;28(4):331-7. doi: 10.1007/s10096-008-0628-x. Epub 2008 Sep 17.

Risk factors for opportunistic infections in infliximab-treated patients: the importance of screening in prevention.

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Hospital Mútua de Terrassa, University of Barcelona, Spain.


We sought to determine factors associated with opportunistic infections (OI) in infliximab-treated patients. A retrospective study cohort (1999-2004) was examined. Nine OI were diagnosed in 94 infliximab-treated patients: tuberculosis (four), visceral leishmaniasis (one), pyogenic muscular abscess (one Salmonella spp. and one Streptococcus pneumoniae), and two viral infections (hepatitis B virus [HBV] and zoster ophthalmicus). The risk for OI was significantly higher in the first year of treatment (odds ratio [OR] 8; 95% confidence interval [CI] 2-50). Previous treatment with more than two immunosuppressive drugs was the only factor related to OI (OR 8.686; 95% CI 1.889-39.943). We identified the subset of patients treated with infliximab who had a higher risk for OI. The screening of latent infections is key to diminishing the incidence of these infections.

[Indexed for MEDLINE]

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