Format

Send to

Choose Destination
J Cereb Blood Flow Metab. 2009 Feb;29(2):221-3. doi: 10.1038/jcbfm.2008.101. Epub 2008 Sep 17.

Reprint: Good laboratory practice: preventing introduction of bias at the bench.

Author information

1
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Erratum in

  • J Cereb Blood Flow Metab. 2009 Jun;29(6):1226. Buchan, Alistair [corrected to Buchan, Alastair].

Abstract

As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

PMID:
18797473
PMCID:
PMC2729492
DOI:
10.1038/jcbfm.2008.101
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center