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Br J Dermatol. 2008 Dec;159(6):1368-9. doi: 10.1111/j.1365-2133.2008.08830.x. Epub 2008 Sep 15.

Control of salicylate intolerance with fish oils.

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Dermatopharmacology Unit, Southampton University Hospitals Trust, Southampton SO16 6YD, UK.


We report three patients with disabling salicylate-induced intolerance who experienced abrogation of symptoms following dietary supplementation with omega-3 polyunsaturated fatty acids (PUFAs). All three patients experienced severe urticaria, asthma requiring systemic steroid therapy and anaphylactic reactions. After dietary supplementation with 10 g daily of fish oils rich in omega-3 PUFAs for 6-8 weeks all three experienced complete or virtually complete resolution of symptoms allowing discontinuation of systemic corticosteroid therapy. Symptoms relapsed after dose reduction. Fish oil appears a safe and effective treatment for this difficult and often serious condition.

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