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FEBS Lett. 1991 Aug 5;287(1-2):203-5.

Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats.

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1
Department of Physiology, Amylin Corporation, San Diego, CA 92121.

Erratum in

  • FEBS Lett 1991 Apr;23(2):153.

Abstract

In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.

PMID:
1879531
DOI:
10.1016/0014-5793(91)80051-4
[Indexed for MEDLINE]
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