Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS Comput Biol. 2008 Jul 4;4(7):e1000104. doi: 10.1371/journal.pcbi.1000104.

Circadian phase resetting via single and multiple control targets.

Author information

1
Department of Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, California, USA.

Abstract

Circadian entrainment is necessary for rhythmic physiological functions to be appropriately timed over the 24-hour day. Disruption of circadian rhythms has been associated with sleep and neuro-behavioral impairments as well as cancer. To date, light is widely accepted to be the most powerful circadian synchronizer, motivating its use as a key control input for phase resetting. Through sensitivity analysis, we identify additional control targets whose individual and simultaneous manipulation (via a model predictive control algorithm) out-perform the open-loop light-based phase recovery dynamics by nearly 3-fold. We further demonstrate the robustness of phase resetting by synchronizing short- and long-period mutant phenotypes to the 24-hour environment; the control algorithm is robust in the presence of model mismatch. These studies prove the efficacy and immediate application of model predictive control in experimental studies and medicine. In particular, maintaining proper circadian regulation may significantly decrease the chance of acquiring chronic illness.

PMID:
18795146
PMCID:
PMC2536509
DOI:
10.1371/journal.pcbi.1000104
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center