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Eur J Pharmacol. 1991 Jun 19;207(2):169-72.

Chronic mianserin treatment decreases 5-HT2 receptor binding without altering 5-HT2 receptor mRNA levels.

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Nancy Pritzker Laboratory of Molecular and Developmental Neurobiology, Department of Psychiatry and Behavioural Sciences, Stanford University Medical Center, CA 94305.


Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P less than 0.05 vs. control). No changes in the amount of 5-HT2 or, as a control, beta-actin mRNAs were found (P greater than 0.05 vs. control). These results indicate that mianserin decreases 5-HT2 radioligand binding without altering steady-state 5-HT2 mRNA levels.

[Indexed for MEDLINE]

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