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Ann Intern Med. 2008 Sep 16;149(6):391-8.

Proton-pump inhibitor use and the risk for community-acquired pneumonia.

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1
University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA.

Abstract

BACKGROUND:

Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP).

OBJECTIVE:

To examine the association between PPI use and CAP in adults followed in general practices in the United Kingdom.

DESIGN:

Nested case-control study.

SETTING:

The General Practice Research Database (1987 to 2002) in the United Kingdom.

PARTICIPANTS:

Patients age 18 years or older with at least 6 months of initial pneumonia-free follow-up in the database. Case patients (n = 80 066) were defined as those who received an incident diagnosis of CAP. Control participants (n = 799 881) were selected by using incidence density sampling, matching on practice site, calendar period, and follow-up duration.

MEASUREMENTS:

Use of PPIs within 30 days before the index date. Adjusted odds ratios (ORs) were estimated by using conditional logistic regression, adjusting for potential confounders.

RESULTS:

Overall, current PPI use was not associated with an increased risk for CAP (adjusted OR, 1.02 [95% CI, 0.97 to 1.08]) or risk for CAP that required hospitalization (adjusted OR, 1.01 [CI, 0.91 to 1.12]). There was a strong increase in risk for CAP associated with current use of PPI therapy that was started within the previous 2 days (adjusted OR, 6.53 [CI, 3.95 to 10.80]), 7 days (adjusted OR, 3.79 [CI, 2.66 to 5.42]), and 14 days (adjusted OR, 3.21 [CI, 2.46 to 4.18]), but there was no statistically significant association for longer-term current PPI therapy. A separate matched case-control analysis, which included the 3 strongest confounders as additional matching factors, yielded similar results as the primary analysis (adjusted OR, 0.96 [CI, 0.91 to 1.02]).

LIMITATIONS:

Adherence to PPI prescription was assumed to be 100%. No radiographic evidence was available to corroborate a diagnosis of CAP.

CONCLUSION:

Proton-pump inhibitor therapy started within the past 30 days was associated with an increased risk for CAP, whereas longer-term current use was not.

PMID:
18794558
[Indexed for MEDLINE]
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