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Genes Dev. 2008 Sep 15;22(18):2479-84. doi: 10.1101/gad.475408.

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.

Abstract

The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduced and the differentiation of upper cortical layer neurons is disturbed. Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ.

PMID:
18794345
PMCID:
PMC2546697
DOI:
10.1101/gad.475408
[Indexed for MEDLINE]
Free PMC Article

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