Format

Send to

Choose Destination
Ann Epidemiol. 2008 Sep;18(9):671-7. doi: 10.1016/j.annepidem.2008.06.006.

HDL-cholesterol and incidence of breast cancer in the ARIC cohort study.

Author information

1
Department of Epidemiology, University of North Carolina at Chapel Hill, NC, USA. Anna_Newton@unc.edu

Abstract

PURPOSE:

An association of low plasma HDL-cholesterol with risk of breast cancer has been suggested by multiple studies; the evidence, however, is not conclusive. We examined the possible association of low HDL-cholesterol with incidence of breast cancer using data from the Atherosclerosis Risk in Communities Study (ARIC) cohort, a prospective study of a randomly selected sample of women and men from four U.S. communities.

METHODS:

Among 7,575 female members of the ARIC cohort, 359 cases of incident breast cancer were ascertained during the follow-up from 1987 through 2000.

RESULTS:

In analysis adjusted for age, race, body mass index, smoking, and reproductive variables, we observed no association of low baseline HDL-cholesterol (<50mg/dL) with incident breast cancer in the total sample (hazard ratio [HR]=1.08 [95% confidence interval (CI), 0.84-1.40]) and a modest association (HR=1.67 [95% CI, 1.06-2.63]) among women who were premenopausal at baseline. No association was observed among women who were postmenopausal at baseline. Removal from analysis of the first 5 years of follow-up did not appreciably change the observed associations.

CONCLUSION:

Results of our study suggest that low HDL-cholesterol among premenopausal women may be a marker of increased breast cancer risk.

PMID:
18794007
PMCID:
PMC2566531
DOI:
10.1016/j.annepidem.2008.06.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center