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Transfus Apher Sci. 2008 Oct;39(2):123-8. doi: 10.1016/j.transci.2008.07.007.

Haemolytic disease of fetus and newborn caused by ABO antibodies in a cisAB offspring.

Author information

1
ShenZhen Institute of Transfusion Medicine, ShenZhen Blood Center, ShenZhen, GuangDong, PR China. zhihui_deng@yahoo.com.com.cn

Abstract

ABO hemolytic disease of fetus and newborn (ABO-HDFN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case of clinically significant ABO-HDFN where the mother was blood group O with elevated IgG anti-A and anti-B titers and delivered a child with an A2B phenotype. This unusual ABO constellation between mother and infant was based on the inheritance of a rare ABO allele encoding for a glycosyltransferase capable of synthesizing both A and B antigens. Because both anti-A and anti-B antibodies may have been involved in hemolysis in this case, it may be relevant to consider the cisAB phenomenon when monitoring ABO-incompatible pregnancies and births.

PMID:
18793871
DOI:
10.1016/j.transci.2008.07.007
[Indexed for MEDLINE]

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