Send to

Choose Destination
Transfus Apher Sci. 2008 Oct;39(2):123-8. doi: 10.1016/j.transci.2008.07.007.

Haemolytic disease of fetus and newborn caused by ABO antibodies in a cisAB offspring.

Author information

ShenZhen Institute of Transfusion Medicine, ShenZhen Blood Center, ShenZhen, GuangDong, PR China.


ABO hemolytic disease of fetus and newborn (ABO-HDFN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case of clinically significant ABO-HDFN where the mother was blood group O with elevated IgG anti-A and anti-B titers and delivered a child with an A2B phenotype. This unusual ABO constellation between mother and infant was based on the inheritance of a rare ABO allele encoding for a glycosyltransferase capable of synthesizing both A and B antigens. Because both anti-A and anti-B antibodies may have been involved in hemolysis in this case, it may be relevant to consider the cisAB phenomenon when monitoring ABO-incompatible pregnancies and births.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center