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Bioorg Med Chem Lett. 2008 Oct 15;18(20):5680-3. doi: 10.1016/j.bmcl.2008.08.052. Epub 2008 Aug 22.

Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.

Author information

1
Department of Organic Chemistry, University of Debrecen, PO Box 20, H-4010 Debrecen, Hungary. somsak@tigris.unideb.hu

Abstract

2-Naphthyl-substituted glucopyranosylidene-spiro-oxathiazole prepared following a novel design principle was found to be the best known glucose analogue inhibitor of rabbit muscle glycogen phosphorylase b (K(i) 160 nM).

PMID:
18793852
DOI:
10.1016/j.bmcl.2008.08.052
[Indexed for MEDLINE]

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