Inhibitors targeting two-component signal transduction

Adv Exp Med Biol. 2008:631:229-36. doi: 10.1007/978-0-387-78885-2_16.

Abstract

A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacteria / genetics
  • Bacterial Physiological Phenomena / drug effects
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Drug Design
  • Drug Resistance, Multiple, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial / physiology
  • Histidine Kinase
  • Microbial Sensitivity Tests
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinases / genetics
  • Protein Kinases / physiology
  • Signal Transduction / drug effects*
  • Signal Transduction / genetics
  • Signal Transduction / physiology
  • User-Computer Interface

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Protein Kinase Inhibitors
  • YycF protein, Bacteria
  • Protein Kinases
  • Histidine Kinase