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Eukaryot Cell. 2008 Nov;7(11):2008-11. doi: 10.1128/EC.00105-08. Epub 2008 Sep 12.

Hydrogen peroxide induces hyphal differentiation in Candida albicans.

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1
Science Building A, Room 211, Ewha Womans University, Seoul 120-750, South Korea.

Abstract

In this study, we demonstrate that hyphal differentiation is induced by the subtoxic concentration of exogenous H(2)O(2) in Candida albicans. This finding is confirmed by the changing intracellular concentration of H(2)O(2). In order to induce the same level of differentiation, low concentrations of exogenous H(2)O(2) are required for the null mutants of the thiol-specific antioxidant and catalase, while higher concentrations are needed for cells treated with ascorbic acid, an antioxidant chemical.

PMID:
18791036
PMCID:
PMC2583538
DOI:
10.1128/EC.00105-08
[Indexed for MEDLINE]
Free PMC Article
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