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Parkinsonism Relat Disord. 2008 Nov;14(7):539-43. doi: 10.1016/j.parkreldis.2008.08.003. Epub 2008 Sep 14.

Genetic variation of Omi/HtrA2 and Parkinson's disease.

Author information

1
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, United States. ross.owen@mayo.edu

Abstract

Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.

PMID:
18790661
PMCID:
PMC2614082
DOI:
10.1016/j.parkreldis.2008.08.003
[Indexed for MEDLINE]
Free PMC Article

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