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Anal Chim Acta. 2008 Oct 3;627(1):50-61. doi: 10.1016/j.aca.2008.03.032. Epub 2008 Mar 22.

Current approaches for global post-translational modification discovery and mass spectrometric analysis.

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1
The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada.

Abstract

More and more attention is being focused on the analysis of post-translational modifications (PTMs) on proteins as researchers are continually learning how essential they are for proper cellular function. As there are hundreds of different types of known PTMs, traditional methods of modification analysis are incapable of comprehensively monitoring for post-translational modifications, a task which is a necessity for truly understanding a cell's biology. This review highlights recent developments in novel multiplexed methods of PTM analysis including: fluorescent stain and immuno-based methods, hardware-based mass spectrometric methods and computational-based mass spectrometric methods. Many of these techniques show great promise and will likely be a valuable resource for the biological community.

PMID:
18790127
DOI:
10.1016/j.aca.2008.03.032
[Indexed for MEDLINE]

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