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Cancer Lett. 2009 Jan 18;273(2):233-42. doi: 10.1016/j.canlet.2008.08.003. Epub 2008 Sep 13.

MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin.

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Tianjin Life Science Research Center, Tianjin Medical University, No. 22, Qi-Xiang-Tai Road, Tianjin 300070, PR China.


MicroRNAs (miRNAs) may function as oncogenes or tumor suppressors. Here, we show that miR-27a is up-regulated in human gastric adenocarcinoma. Suppression of miR-27a inhibits gastric cancer cell growth. Subsequently, prohibitin is identified as a potential miR-27a target, combining bioinformatics and microarray analysis. EGFP report experiment also confirms that the 3' untranslated region (3'UTR) of prohibitin carries the directly binding site of miR-27a. After knockdown of miR-27a in gastric cancer cells, mRNA level and protein level of prohibitin are both elevated. Down-regulation of prohibitin by miR-27a may explain why suppression of miR-27a can inhibit gastric cancer cell growth, further supporting that miR-27a functions as an oncogene.

[Indexed for MEDLINE]

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