Format

Send to

Choose Destination
Environ Int. 2009 Apr;35(3):512-5. doi: 10.1016/j.envint.2008.07.023. Epub 2008 Sep 11.

Transport pathways for arsenic and selenium: a minireview.

Author information

1
Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA. brosen@med.wayne.edu

Abstract

Arsenic and selenium are metalloids found in the environment. Arsenic is considered to pose the most significant potential threat to human health based on frequency of occurrence, toxicity and human exposure. Selenium, on the other hand, ranks only 147th in toxicity but, in contrast to arsenic, is a required micronutrient. Whether a toxin or micronutrient, their metabolism requires that cells to accumulate these metalloids. In this review we discuss the membrane proteins that transport arsenic and selenium into cells, from bacteria to humans, as well as some of the efflux proteins involved in detoxification.

PMID:
18789529
PMCID:
PMC2719050
DOI:
10.1016/j.envint.2008.07.023
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center