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FEBS Lett. 2008 Oct 29;582(25-26):3585-9. doi: 10.1016/j.febslet.2008.09.002. Epub 2008 Oct 10.

PspA can form large scaffolds in Escherichia coli.

Author information

1
Institute of Biology/Microbiology, University of Halle-Wittenberg, Kurt-Mothes-Strasse 3, D-06120 Halle, Germany.

Abstract

The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.

PMID:
18789328
DOI:
10.1016/j.febslet.2008.09.002
[Indexed for MEDLINE]
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