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BMC Cancer. 2008 Sep 14;8:259. doi: 10.1186/1471-2407-8-259.

Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines.

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  • 1Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Wellington Road, CLAYTON, Victoria 3800, Australia. danielle.smith@med.monash.edu.au

Abstract

BACKGROUND:

Many cancers preferentially meet their energy requirements through the glycolytic pathway rather than via the more efficient oxidative phosphorylation pathway. It is thought that this is an important adaptation in cancer malignancy. We investigated whether use of glycolysis for energy production even in the presence of oxygen (known as the Warburg effect) varied between neuroblastoma cell lines with or without MYCN amplification (a key indicator of poor disease outcome in neuroblastoma).

METHODS:

We examined ATP and lactate production, oxygen consumption and mitochondrial energisation status for three neuroblastoma cell lines with varying degrees of MYCN amplification and MYCN expression.

RESULTS:

We found no correlation between MYCN expression and the Warburg effect in the cell lines investigated.

CONCLUSION:

Our results suggest preferential use of glycolysis for energy production and MYCN expression may be independent markers of neuroblastoma malignancy in vitro if not in vivo.

PMID:
18789162
PMCID:
PMC2551622
DOI:
10.1186/1471-2407-8-259
[PubMed - indexed for MEDLINE]
Free PMC Article
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