Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Pharmacol. 2008 Dec;8(6):697-703. doi: 10.1016/j.coph.2008.08.009. Epub 2008 Sep 26.

Visceral analgesics: drugs with a great potential in functional disorders?

Author information

1
Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA. sbradesi@ucla.edu

Abstract

Irritable bowel syndrome remains an incompletely understood, common syndrome with significant unmet medical needs. In IBS patients, abdominal pain is a primary factor related to quality of life impairment, symptom severity and health care utilization, and chronic visceral hyperalgesia has been identified as an important aspect of IBS pathophysiology. However, the development of therapies aimed at reducing this hyperalgesia (visceral analgesics) has been only partially successful despite preclinical evidence supporting the potential usefulness of several preclinical compounds aimed at peripheral as well as central targets.

PMID:
18786654
PMCID:
PMC2651816
DOI:
10.1016/j.coph.2008.08.009
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center