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Curr Biol. 2008 Sep 9;18(17):R769-R776. doi: 10.1016/j.cub.2008.07.018.

Timing in cellular Ca2+ signaling.

Author information

1
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

Abstract

Calcium (Ca2+) signals are generated across a broad time range. Kinetic considerations impact how information is processed to encode and decode Ca2+ signals, the choreography of responses that ensure specific and efficient signaling and the overall temporal amplification such that ephemeral Ca2+ signals have lasting physiological value. The reciprocal importance of timing for Ca2+ signaling, and Ca2+ signaling for timing is exemplified by the altered kinetic profiles of Ca2+ signals in certain diseases and the likely role of basal Ca2+ fluctuations in the perception of time itself.

PMID:
18786382
PMCID:
PMC3236564
DOI:
10.1016/j.cub.2008.07.018
[Indexed for MEDLINE]
Free PMC Article

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