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Breast Cancer Res Treat. 2009 Aug;116(3):551-62. doi: 10.1007/s10549-008-0167-2. Epub 2008 Sep 11.

Alcohol and folate intake and breast cancer risk in the WHI Observational Study.

Author information

1
Division of General Internal Medicine, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA. cduffy@lifepsan.org

Abstract

BACKGROUND:

Alcohol increases breast cancer risk. Epidemiological studies suggest folate may modify this relationship.

OBJECTIVE:

To examine the relationship among breast cancer, alcohol and folate in the Women's Health Initiative-Observational Study (WHI-OS).

METHODS:

88,530 postmenopausal women 50-79 years completed baseline questionnaires between October 1993 and December 1998, which addressed alcohol and folate intake and breast cancer risk factors. Cox proportional hazards analysis examined the relationship between self-reported baseline alcohol and folate intake and incident breast cancer.

RESULTS:

1,783 breast cancer cases occurred over 5 years. Alcohol was associated with increased risk of breast cancer (RR = 1.005, 95%CI 1.001-1.009). Risk increased with consumption of alcohol (up to 5 g/d, adjusted HR = 1.10, 95%CI 0.96-1.32; >5-15 g/d HR = 1.14, 95%CI 0.99-1.31; and >15 g/d HR = 1.13 95%CI 0.96-1.32). We found no significant interaction between alcohol and folate in our adjusted model.

CONCLUSIONS:

We found no evidence for folate attenuating alcohol's effect on breast cancer risk in postmenopausal women. Our results may be due to misclassification of folate intake or the relatively short follow-up period.

PMID:
18785003
PMCID:
PMC4104749
DOI:
10.1007/s10549-008-0167-2
[Indexed for MEDLINE]
Free PMC Article

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