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Nat Rev Neurosci. 2008 Oct;9(10):788-96. doi: 10.1038/nrn2345. Epub 2008 Sep 11.

Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms.

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1
University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. derubeis@psych.upenn.edu

Abstract

Depression is one of the most prevalent and debilitating of the psychiatric disorders. Studies have shown that cognitive therapy is as efficacious as antidepressant medication at treating depression, and it seems to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. A precise specification of these mechanisms might one day be used to guide treatment selection and improve outcomes.

PMID:
18784657
PMCID:
PMC2748674
DOI:
10.1038/nrn2345
[Indexed for MEDLINE]
Free PMC Article

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