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Adv Exp Med Biol. 2008;641:88-97.

Reverse engineering models of cell cycle regulation.

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  • 1Materials Structure and Modeling Research Group of the Hungarian Academy of Sciences, Budapest, Hungary. csikasz@mail.bme.hu

Abstract

From general considerations of the basic physiological properties of the cell division cycle, we deduce what the dynamical properties of the underlying molecular control system must be. Then, taking a few hints from the biochemistry of cyclin-dependent kinases (the master regulators of the eukaryotic cell cycle), we guess what molecular mechanisms must be operating to produce the desired dynamical properties of the control system.

PMID:
18783174
[PubMed - indexed for MEDLINE]
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