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J Clin Endocrinol Metab. 2008 Dec;93(12):4600-5. doi: 10.1210/jc.2006-2409. Epub 2008 Sep 9.

Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials.

Author information

1
Department of Pediatrics, Mayo Clinic, W18A, 200 First Street SW, Rochester, Minnesota 55905, USA.

Abstract

CONTEXT:

The efficacy of treatments for pediatric obesity remains unclear.

OBJECTIVE:

We performed a systematic review of randomized trials to estimate the efficacy of nonsurgical interventions for pediatric obesity.

DATA SOURCES:

Librarian-designed search strategies of nine electronic databases from inception until February 2006, review of reference lists from published reviews, and content expert advice provided potentially eligible studies.

STUDY SELECTION:

Eligible studies were randomized trials of overweight children and adolescents assessing the effect of nonsurgical interventions on obesity outcomes.

DATA EXTRACTION:

Independently and in duplicate, reviewers assessed the quality of each trial and collected data on interventions and outcomes.

DATA SYNTHESIS:

Of 76 eligible trials, 61 had complete data for meta-analysis. Short-term medications were effective, including sibutramine [random-effects pooled estimate of body mass index (BMI) loss of 2.4 kg/m(2) with a 95% confidence interval (CI) of 1.8-3.1; proportion of between-study inconsistency not due to chance (I(2)) = 30%] and orlistat (BMI loss = 0.7 kg/m(2); CI = 0.3-1.2; I(2) = 0%). Trials that measured the effect of physical activity on adiposity (i.e. percent body fat and fat-free mass) found a moderate treatment effect (effect size = -0.52; CI = -0.73 to -0.30; I(2) = 0%), whereas trials measuring the effect on BMI found no significant effect (effect size = -0.02; CI = -0.21 to 0.18; I(2) = 0%), but reporting bias may explain this finding. Combined lifestyle interventions (24 trials) led to small changes in BMI.

CONCLUSIONS:

Limited evidence supports the short-term efficacy of medications and lifestyle interventions. The long-term efficacy and safety of pediatric obesity treatments remain unclear.

PMID:
18782881
DOI:
10.1210/jc.2006-2409
[Indexed for MEDLINE]

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