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Clin Infect Dis. 2008 Oct 15;47(8):e69-73. doi: 10.1086/592073.

Diagnosis of coccidioidomycosis with use of the Coccidioides antigen enzyme immunoassay.

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1
MiraVista Diagnostics, Indianapolis, Indiana 46241, USA.

Abstract

BACKGROUND:

We have previously shown antigenuria in patients with coccidioidomycosis through use of the Histoplasma antigen enzyme immunoassay (EIA), and now we have developed a specific Coccidioides antigen EIA.

METHODS:

The Coccidioides EIA uses antibodies to Coccidioides galactomannan. The sensitivity of the Coccidioides and Histoplasma EIAs was evaluated in patients with more-severe coccidioidomycosis, and the specificity of these EIAs was evaluated in patients with nonfungal infections, in patients with other endemic mycoses, and in healthy individuals.

RESULTS:

Among patients in the present study, antigenuria was detected in 70.8% of patients with coccidioidomycosis with use of the Coccidioides EIA and in 58.3% of patients with use of the Histoplasma EIA. Antigenuria was absent in 99.4% of healthy individuals, patients with nonfungal infections, and patients with noninfectious conditions. Cross-reactions with other endemic mycoses were observed in 10.7% of patients.

CONCLUSIONS:

The Coccidioides EIA has potential to be useful in the rapid diagnosis of more-severe forms of coccidioidomycosis.

PMID:
18781884
DOI:
10.1086/592073
[Indexed for MEDLINE]
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