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Pharmacogenomics. 2008 Sep;9(9):1323-30. doi: 10.2217/14622416.9.9.1323.

Identifying genetic components of drug response in mice.

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1
Center for Human Genetic Research, Massachusetts General Hospital, MA, USA. chrisc@chgr.mgh.harvard.edu

Abstract

Individual variations in drug response are crucial factors in both the development and deployment of therapy, yet we are still woefully ignorant of the majority of this genetic basis. Here we discuss the convergence of genetics and genomics to dissect such pharmacological variation, with emphasis on satisfying the requirements of both genetics and pharmacology itself, the appropriate use of model organisms and the often overlooked power of genetic dissection to inform understanding of physiological process.

PMID:
18781858
DOI:
10.2217/14622416.9.9.1323
[Indexed for MEDLINE]
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