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Expert Opin Ther Targets. 2008 Oct;12(10):1275-87. doi: 10.1517/14728222.12.10.1275 .

Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target.

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1
The University of Chicago, Ben May Department for Cancer Research, 929 East 57th Street, Chicago, IL 60637, USA.

Abstract

BACKGROUND:

Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein (PEBP) family that is expressed in both prokaryotic and euakaryotic organisms.

OBJECTIVE:

In this review, we discuss the role of RKIP as a modulator of signal transduction, the relationship of RKIP to other members of the PEBP family, and the role of RKIP in human health and disease.

RESULTS/CONCLUSION:

In mammals, RKIP regulates activation of MAPK, NF-kappaB and G protein coupled receptors (GPCRs). As a modulator of key signaling pathways, RKIP affects various cellular processes including cell differentiation, the cell cycle, apoptosis and cell migration. Emerging evidence suggests that RKIP is implicated in several human diseases or disorders, among them metastatic tumorigenesis and Alzheimer's disease.

PMID:
18781826
DOI:
10.1517/14728222.12.10.1275
[Indexed for MEDLINE]
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