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Hum Genet. 2008 Oct;124(3):287-8. doi: 10.1007/s00439-008-0544-2. Epub 2008 Sep 10.

LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.

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1
Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Outram Road, Singapore, 169608, Singapore. gnrtek@sgh.com.sg

Abstract

We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese.

PMID:
18781329
DOI:
10.1007/s00439-008-0544-2
[Indexed for MEDLINE]
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