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J Cancer Res Clin Oncol. 2009 Mar;135(3):439-49. doi: 10.1007/s00432-008-0469-0. Epub 2008 Sep 10.

Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection.

Author information

1
Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical School, Fudan University, 136 Yi Xue Yuan Road, 200032, Shanghai, People's Republic of China.

Abstract

PURPOSE:

To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection.

METHODS:

The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/T(M) infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.

RESULTS:

High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&T(M) infiltration for DFS (P = 0.004) and OS (P = 0.040).

CONCLUSIONS:

Both TAM infiltration alone and concomitant infiltration of TAM&T(M) are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.

PMID:
18781326
DOI:
10.1007/s00432-008-0469-0
[Indexed for MEDLINE]

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