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Eur J Nucl Med Mol Imaging. 2009 Feb;36(2):275-86. doi: 10.1007/s00259-008-0935-6. Epub 2008 Sep 9.

Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects.

Author information

1
Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland. jueshi@utu.fi

Abstract

PURPOSE:

[(11)C]Carfentanil has been widely used in positron emission tomography (PET) studies for measuring micro-opioid receptor binding in humans, but the reproducibility of the binding parameter estimates is unknown.

MATERIALS AND METHODS:

Eight healthy volunteers were scanned twice during the same day with [(11)C]carfentanil PET, and binding to receptors was assessed with both reference tissue and arterial plasma input-based models using region of interest (ROI) and voxel-based quantification.

RESULTS:

The two-tissue compartmental model distribution volume (V(T)) was highly reproducible as indicated by low variability (VAR < 6%) and high intraclass correlation coefficients (ICC > 0.93). BP(ND) (BP relative to the nondisplaceable tissue compartment) was also highly reproducible (VAR < 10%, ICC > 0.90) both at ROI- and voxel-level, and reference tissue-based models provided stable estimates after 40 min.

CONCLUSIONS:

The reproducibility of [(11)C]carfentanil binding parameter estimates is excellent with outcome measures based on both arterial plasma and reference tissue input, and a scanning time of 40 min appears sufficient.

PMID:
18779961
DOI:
10.1007/s00259-008-0935-6
[Indexed for MEDLINE]

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