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J Antimicrob Chemother. 2008 Dec;62(6):1241-4. doi: 10.1093/jac/dkn380. Epub 2008 Sep 8.

UK epidemic Escherichia coli strains A-E, with CTX-M-15 beta-lactamase, all belong to the international O25:H4-ST131 clone.

Author information

1
Department of Medical Microbiology, School of Medicine, University of Manchester, Clinical Sciences Building, Manchester Royal Infirmary, Manchester M13 9WL, UK.

Abstract

OBJECTIVES:

Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum beta-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E, as determined by PFGE. The present study was carried out to define the relationship between these two groups of pathogenic E. coli.

METHODS:

Multilocus sequence typing and PFGE were used for molecular characterization of a collection of 61 ESBL-producing E. coli isolates from across the UK.

RESULTS:

Strains A to E all belonged to the ST131 clone, further underscoring the epidemiological importance of this lineage.

CONCLUSIONS:

The future spread of the ST131 clone, and its UK variants, should be monitored closely and the pathogenic mechanisms explaining their success should be investigated.

PMID:
18779256
DOI:
10.1093/jac/dkn380
[Indexed for MEDLINE]

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