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Chest. 2008 Sep;134(3):628-630. doi: 10.1378/chest.08-0400.

Asthma management by monitoring sputum neutrophil count.

Author information

1
Firestone Institute for Respiratory Health and Department of Medicine, McMaster University, Hamilton, ON, Canada.
2
Department of Molecular Medicine, McMaster University, Hamilton, ON, Canada.
3
Firestone Institute for Respiratory Health and Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: parames@mcmaster.ca.

Abstract

We report the utility of quantitative cell counts in sputum in monitoring therapy of a patient with poorly controlled asthma. Recurrent neutrophilic bronchitis without an eosinophilic bronchitis led to the identification of Chlamydophila pneumoniae as the cause of bronchitis and asthma exacerbation. Serial examination of blood and sputum by polymerase chain reaction for C pneumoniae helped to prevent exacerbations by prophylactic antibiotic therapy, reduce the dose of prednisone and inhaled corticosteroids, and improve asthma control.

PMID:
18779198
DOI:
10.1378/chest.08-0400
[Indexed for MEDLINE]

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