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Fertil Steril. 2009 May;91(5 Suppl):2012-9. doi: 10.1016/j.fertnstert.2008.04.039. Epub 2008 Sep 7.

Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles.

Author information

1
Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA. isouter@partners.org

Abstract

OBJECTIVE:

To assess whether gonadotropin-induced changes in E(2) alter serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and proinflammatory cytokines.

DESIGN:

Prospective collection of serum in patients undergoing IVF.

SETTING:

University hospital.

PATIENT(S):

Twenty-four infertile women.

INTERVENTION(S):

Serum collection at baseline, in the mid and late follicular phases, at oocyte retrieval, and in the mid and late luteal phases.

MAIN OUTCOME MEASURE(S):

Samples were assayed for sVCAM-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and E(2).

RESULT(S):

The VCAM-1 was maximally suppressed in the luteal phase. Luteal sVCAM-1 levels correlated [1] positively with the patient's age, units of gonadotropins, day 3 FSH levels and [2] negatively with [a] the follicular, retrieval, and luteal E(2) levels and [b] the number of preovulatory follicles and oocytes retrieved. Similar correlations were noted in the late luteal phase. Serum TNF-alpha reached a peak in the mid-follicular phase and a nadir in the luteal phase. The TNF-alpha levels at retrieval correlated [1] positively with the patient's age and [2] negatively with E(2) and number of preovulatory follicles and retrieved oocytes. The IL-6 levels were suppressed in the follicular phase and correlated negatively with E(2) levels.

CONCLUSION(S):

Changes in E(2) levels seen during gonadotropin stimulation significantly alter VCAM-1 expression and induce changes in serum IL-6 and TNF-alpha levels.

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