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Br J Pharmacol. 2009 May;157(2):153-65. doi: 10.1038/bjp.2008.349.

Viral vectors: from virology to transgene expression.

Author information

1
Université de Lyon, F69000, Lyon, France.

Abstract

In the late 1970s, it was predicted that gene therapy would be applied to humans within a decade. However, despite some success, gene therapy has still not become a routine practise in medicine. In this review, we will examine the problems, both experimental and clinical, associated with the use of viral material for transgenic insertion. We shall also discuss the development of viral vectors involving the most important vector types derived from retroviruses, adenoviruses, herpes simplex viruses and adeno-associated viruses.

PMID:
18776913
PMCID:
PMC2629647
DOI:
10.1038/bjp.2008.349
[Indexed for MEDLINE]
Free PMC Article

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