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Nat Neurosci. 2008 Oct;11(10):1143-5. doi: 10.1038/nn.2175. Epub 2008 Sep 7.

Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory.

Author information

1
Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Abstract

We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.

PMID:
18776892
PMCID:
PMC3038669
DOI:
10.1038/nn.2175
[Indexed for MEDLINE]
Free PMC Article

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