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Pediatr Infect Dis J. 2008 Oct;27(10):946-8. doi: 10.1097/INF.0b013e318175d85c.

Acyclovir-resistant chronic verrucous vaccine strain varicella in a patient with neuroblastoma.

Author information

1
Division of Pediatric Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA. Coleman.Bryan@med.navy.mil

Abstract

A 21-month-old girl with neuroblastoma developed chronic verrucous Oka strain varicella-zoster infection during chemotherapy. Virus isolated from the patient demonstrated high-level acyclovir resistance, and its thymidine kinase had no in vitro enzymatic activity. After foscarnet therapy, she underwent stem cell transplantation without varicella reactivation. This is only the second reported case of resistant varicella zoster virus caused by Oka strain virus.

PMID:
18776818
DOI:
10.1097/INF.0b013e318175d85c
[Indexed for MEDLINE]

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