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Nucleic Acids Symp Ser (Oxf). 2008;(52):511-2. doi: 10.1093/nass/nrn259.

The HIV-2 TAR RNA domain as a potential source of viral-encoded miRNA. A reconnaissance study.

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1
Laboratory of Structural Chemistry of Nucleic Acids, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 PoznaƄ, Poland.

Abstract

Recently, it has been reported that HIV-1 TAR RNA element releases functionally competent miRNAs upon processing by Dicer enzyme. Here, we extend the analysis of miRNA viral-encoding potential to the TAR RNA of the HIV-2. Using in vitro Dicer cleavages and computer-aided analysis we have found that the 124-mer TAR RNA domain, present at the 5' end of HIV-2 mRNAs, putatively encodes pre-miRNAs. When deduced sequences of the viral-encoded miRNAs were matched against the database of human mRNA 3'-UTRs, it appeared that two miRNA candidates may target a large number of cellular transcripts.

PMID:
18776478
DOI:
10.1093/nass/nrn259
[Indexed for MEDLINE]
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