Abstract
Two diastereomers of 7-methylguanosine 5'-O-(1-thiotriphosphate) have been synthesized and resolved by RP HPLC. Preliminary studies revealed that these new analogs of mRNA cap are characterized by high affinity for eIF4E, resistance towards DcpS pyrophosphatase and high potency to inhibit cap-dependent translation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Eukaryotic Initiation Factor-4E / metabolism
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Guanosine Triphosphate / analogs & derivatives*
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Guanosine Triphosphate / chemical synthesis
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Guanosine Triphosphate / chemistry
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Guanosine Triphosphate / pharmacology
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Protein Biosynthesis / drug effects*
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Protein Synthesis Inhibitors / chemical synthesis
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Protein Synthesis Inhibitors / chemistry*
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Protein Synthesis Inhibitors / pharmacology
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RNA Cap Analogs / chemical synthesis
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RNA Cap Analogs / chemistry*
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RNA Cap Analogs / pharmacology
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Rabbits
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Stereoisomerism
Substances
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7-methylguanosine 5'-O-(1-thiotriphosphate)
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Eukaryotic Initiation Factor-4E
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Protein Synthesis Inhibitors
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RNA Cap Analogs
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Guanosine Triphosphate