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Nucleic Acids Symp Ser (Oxf). 2008;(52):67-8. doi: 10.1093/nass/nrn034.

Protein-facilitated ribozyme folding and catalysis.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA. nora.zingler@yale.edu

Abstract

In vivo, large RNAs rely on proteins to fold to their native conformation. In the case of the S. cerevisiae group II intron ai5 gamma, the DEAD-box protein Mss116 has been shown to promote the formation of the catalytically active structure. However, it is a matter of debate whether it does this by stabilizing on-pathway intermediates or by disrupting misfolded structures. Here we present the available experimental evidence to distinguish between those mechanisms and discuss the possible interpretations.

PMID:
18776256
DOI:
10.1093/nass/nrn034
[Indexed for MEDLINE]

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