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Child Adolesc Psychiatr Clin N Am. 2008 Oct;17(4):713-38, vii. doi: 10.1016/j.chc.2008.06.009.

Treatment of inattention, overactivity, and impulsiveness in autism spectrum disorders.

Author information

1
Department of Psychology, Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA. aman.1@osu.edu

Abstract

We reviewed the recent literature on medicines used to manage inattention, impulsiveness, and overactivity in children with pervasive developmental disorders (autistic disorder, pervasive developmental disorder not otherwise specified, Asperger's disorder) using computer searches of pharmacologic studies. A substantial number of reports were identified and summarized. The literature tends to be dominated by uncontrolled studies, although the number of controlled trials is growing. Findings are described for psychostimulants, noradrenergic reuptake inhibitors, antipsychotics, alpha adrenergic agonists, antidepressants, anxiolytics, cholinesterase inhibitors, N-methyl-D-aspartate receptor blockers, and antiepileptic mood stabilizers. Evidence for a positive effect is strongest for psychostimulants, noradrenergic reuptake inhibitors, antipsychotics, and alpha adrenergic agonists. Evidence for efficacy seems weakest for newer antidepressants, anxiolytics, and mood stabilizers.

PMID:
18775366
PMCID:
PMC3805750
DOI:
10.1016/j.chc.2008.06.009
[Indexed for MEDLINE]
Free PMC Article

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