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Cell. 2008 Sep 5;134(5):718-9. doi: 10.1016/j.cell.2008.08.024.

A protein scaffold plays matchmaker for chordin.

Author information

1
Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California, Berkeley, CA 94720-3200, USA.

Abstract

In this issue, Inomata et al. (2008) report that the scaffold protein Olfactomedin 1 (ONT1) recruits the Tolloid proteases to their substrate Chordin, an antagonist of bone morphogenetic proteins (BMPs), during development of the frog embryo. Consequently, ONT1 expression in the organizer of the late gastrula stabilizes the gradient of BMP signaling that is essential for dorsoventral patterning.

PMID:
18775302
DOI:
10.1016/j.cell.2008.08.024
[Indexed for MEDLINE]
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