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Cell. 2008 Sep 5;134(5):703-7. doi: 10.1016/j.cell.2008.08.021.

Cancer cell metabolism: Warburg and beyond.

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1
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Cambridge, MA 02142, USA.

Abstract

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

PMID:
18775299
DOI:
10.1016/j.cell.2008.08.021
[Indexed for MEDLINE]
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