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Pediatr Diabetes. 2008 Aug;9(4 Pt 2):426-30. doi: 10.1111/j.1399-5448.2008.00359.x.

A teenage girl with cystic fibrosis-related diabetes, diabetic ketoacidosis, and cerebral edema.

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Division of Endocrinology, Department of Medicine, Children's Hospital Boston, Boston, MA 02115, USA.


Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes, most commonly associated with type 1 diabetes. Here, we report the case of a 17-yr-old girl with cystic fibrosis and a prior diagnosis of cystic fibrosis-related diabetes (CFRD) who presented with DKA in the setting of insulin omission and glucocorticoid use. During the course of treatment for DKA, her neurologic status declined and head computerized tomography confirmed cerebral edema. Recognition of DKA and cerebral edema allowed for timely treatment, and the patient recovered without sequelae. This is the first report of DKA complicated by cerebral edema that is attributable to CFRD.

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