Format

Send to

Choose Destination
Trends Genet. 2008 Oct;24(10):498-510. doi: 10.1016/j.tig.2008.07.005. Epub 2008 Sep 4.

Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.

Author information

1
Department of Neuroscience, Erasmus University Medical Center, 3000 CA, Rotterdam, The Netherlands.

Abstract

Defects in rat sarcoma viral oncogene homolog (RAS)-extracellular signal regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (MTOR) signaling pathways have recently been shown to cause several genetic disorders classified as neuro-cardio-facial-cutaneous (NCFC) and Hamartoma syndromes. Although these pathways are well-known players in cell proliferation and cancer, their role in cognitive function is less appreciated. Here, we focus on the cognitive problems associated with mutations in the RAS-ERK and PI3K-MTOR signaling pathways and on the underlying mechanisms revealed by recent animal studies. Cancer drugs have been shown to reverse the cognitive deficits in mouse models of NCFC and Hamartoma syndromes, raising hopes for clinical trials.

PMID:
18774199
DOI:
10.1016/j.tig.2008.07.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center