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Cell Death Differ. 2009 Jan;16(1):57-69. doi: 10.1038/cdd.2008.130. Epub 2008 Sep 5.

Eating the enemy within: autophagy in infectious diseases.

Author information

1
Howard Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

Abstract

Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.

PMID:
18772897
PMCID:
PMC2736877
DOI:
10.1038/cdd.2008.130
[Indexed for MEDLINE]
Free PMC Article

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