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Am J Obstet Gynecol. 2008 Sep;199(3):303.e1-3. doi: 10.1016/j.ajog.2008.06.068.

Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection.

Author information

1
Center for Women's Reproductive Health, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.

Abstract

OBJECTIVE:

We assessed the impact of an extended-spectrum antibiotic prophylaxis regimen (azithromycin in addition to recommended narrow-spectrum cephalosporin) on postcesarean incisional wound infection.

STUDY DESIGN:

Data from prospective surveillance of surgical site infections at our institution were used to compare incidence in postcesarean incisional wound infection for 3 consecutive time periods of antibiotic prophylaxis: (1) standard (ie, cephalosporin only, 1992-1996); (2) clinical trial of extended spectrum (ie, extended vs cephalosporin only, 1997-1999); and (3) routine use of extended spectrum (2001-2006).

RESULTS:

The incidence of postcesarean incisional wound infections decreased progressively from 3.1% to 2.4% and then to 1.3% over the 3 consecutive periods (P value for trend < .002).

CONCLUSION:

Increasing the use of extended-spectrum antibiotic prophylaxis at our institution over 3 time periods was associated with a decreasing trend in postcesarean incisional wound infection.

PMID:
18771992
DOI:
10.1016/j.ajog.2008.06.068
[Indexed for MEDLINE]

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