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Semin Immunol. 2008 Aug;20(4):228-35. doi: 10.1016/j.smim.2008.08.003. Epub 2008 Sep 3.

Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system.

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Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 929 East 57th Street, GCIS W522, Chicago, IL 60637, USA.


Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, recent evidence suggests the involvement of microRNAs. In this review we attempt to integrate these two types of regulatory components into circuits that dictate cell fate choices leading to the generation of innate as well as adaptive immune cells. The developmental circuits are placed in the context of a revised scheme for hematopoiesis that suggests that both the innate (myeloid) and adaptive (lymphoid) lineages of the immune system arise from a common progenitor.

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