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Curr Biol. 2008 Oct 28;18(20):1537-45. doi: 10.1016/j.cub.2008.08.033. Epub 2008 Sep 4.

Large ventral lateral neurons modulate arousal and sleep in Drosophila.

Author information

1
Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA.

Abstract

BACKGROUND:

Large ventral lateral clock neurons (lLNvs) exhibit higher daytime-light-driven spontaneous action-potential firing rates in Drosophila, coinciding with wakefulness and locomotor-activity behavior. To determine whether the lLNvs are involved in arousal and sleep/wake behavior, we examined the effects of altered electrical excitation of the LNvs.

RESULTS:

LNv-hyperexcited flies reverse the normal day-night firing pattern, showing higher lLNv firing rates at night and pigment-dispersing-factor-mediated enhancement of nocturnal locomotor-activity behavior and reduced quantity and quality of sleep. lLNv hyperexcitation impairs sensory arousal, as shown by physiological and behavioral assays. lLNv-hyperexcited flies lacking sLNvs exhibit robust hyperexcitation-induced increases in nocturnal behavior, suggesting that the sLNvs are not essential for mediation of arousal.

CONCLUSIONS:

Light-activated lLNvs modulate behavioral arousal and sleep in Drosophila.

PMID:
18771923
PMCID:
PMC2597195
DOI:
10.1016/j.cub.2008.08.033
[Indexed for MEDLINE]
Free PMC Article

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