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Ann Nutr Metab. 2008;53(1):33-42. doi: 10.1159/000153006. Epub 2008 Sep 4.

Efficacy and safety of Chinese black tea (Pu-Ehr) extract in healthy and hypercholesterolemic subjects.

Author information

1
Research and Development Department, Nippon Supplement, Inc., Osaka, Japan. fujita@nippon-sapuri.co.jp

Abstract

BACKGROUND/AIMS:

Water-extracted Chinese black tea (Pu-Ehr) exerts a precipitating effect on mixed bile salt micelles in foods. The amount of black tea extract (BTE) effective for hypercholesterolemia (HC) was examined in humans.

MATERIALS AND METHODS:

Animals (test 1) and humans (tests 2-5) were given BTE in the following studies: (test 1) an acute 2-week toxicity test conducted in mice with 2,000 mg/kg BTE or saline; (test 2) a dose-finding 8-week toxicity study with excessive BTE ingestion (0.75 or 1 g/day) in 10 healthy and 10 borderline HC subjects; (test 3) a 1-day acute toxicity test using a (10 g) single-bolus study (n = 10); (test 4) a 5-week long-term safety test (5 g/day, n = 11), and (test 5) a 4-month noncomparative study in 21 HC patients ingesting 1 g/day.

RESULTS:

The safety study showed no changes in hematological or relevant biochemical parameters in both mice and humans in the acute and long-term toxicity tests. In test 5, significant reductions in total and low-density lipoprotein cholesterol levels accompanied by significant decreases in body weight were observed without affecting other biochemical parameters.

CONCLUSIONS:

BTE significantly reduced blood cholesterol levels in humans and may prove safe and useful in preventing and improving metabolic syndrome-induced arteriosclerosis and/or obesity.

PMID:
18769024
DOI:
10.1159/000153006
[Indexed for MEDLINE]

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